EFFECTS OF THE AURORA KINASE INHIBITORS AZD1152-HQPA AND ZM447439 ON GROWTH ARREST AND POLYPLOIDY IN ACUTE MYELOID LEUKEMIA CELL LINES AND PRIMARY BLASTS

Background Aurora kinases play an essential role in the orchestration of chromosome separation and cytokinesis during mitosis.Small-molecule inhibition of the aurora kinases has been shown to result in inhibition of cell division, phosphorylation of histone H3 and Gift Card the induction of apoptosis in a number of cell systems.These characteristic

Background: Emotional dysregulation, particularly unconscious catastrophic cognitions, plays a pivotal role in the genesis of panic disorder (PD).However, no studies have yet applied the percentage of Rockers amplitude fluctuation (PerAF) metric in resting-state functional magnetic resonance imaging to examine spontaneous neural functioning and its

According to dimensional models of personality pathology, deficits in interpersonal (intimacy and empathy) and self (identity and self-direction) function (Criterion A) are core to all personality disorders.These aspects of personality functioning (Criterion A) have seldom been evaluated for how they might relate to one another in the context of pe

Background: The purpose of the study was to assess the knowledge, attitude, and practices toward the prevention of malaria among pregnant women aged 18-45 years at Busibo health center III, Lwengo district.Methodology: A cross-section study design was employed as a study design with a simple random technique as a sampling technique.Data were collec

Priapism is a prolonged pathologic erection situation that occurs after sexual stimulation or without sexual stimulation.This condition Cyber Tattoo Machines is divided into two types, ischemic (low-flow, veno-occlusive) and non-ischemic (high-flow, arterial).A 68-year-old male patient applied to our clinic with the complaints of hardness and pain